Oral cancer is responsible for 128,000 deaths per year, and nearly all of them are preventable. There are currently no recommended screening tests, but studies on low-cost examina ons are ongoing. These include the examina on of oral cavity autofluorescence (loss of fluorescence may be related to dysplasia or cancer). The GOCCLES device (fig. 1), patented at the Catholic University of the Sacred Heart of Rome, consists of filters that show oral mucosal autofluorescence abnormali es when used together with any dental curing light. The aim of the study is to demonstrate that GOCCLES allows an effec ve examina on of autofluorescence in the dental prac ce.